Hormone replacement therapy may not be appropriate for individuals with a current or prior history of estrogen-receptor–positive cancers, including breast, uterine, or ovarian cancer, although testosterone therapy may still be considered in select cases. Patients with a history of blood clots, liver disease, uncontrolled high blood pressure, or pregnancy may require alternative treatment options, which can include lifestyle modifications, nutritional support, or non-hormonal medications.

Testosterone Replacement Therapy (TRT) uses bioidentical hormones designed to match those naturally produced by the body. These hormones, often derived from plant sources, can be customized by specialized pharmacies to create individualized dosing tailored to each patient’s needs. While some bioidentical hormone therapies are FDA-approved, compounded formulations are not, but allow for greater personalization of treatment. Because these hormones closely mirror the body’s natural chemistry, TRT may offer improved tolerability and a more individualized approach compared to synthetic alternatives.

Testosterone Replacement Therapy (TRT) uses bioidentical hormones that closely replicate those naturally produced by the body. Often sourced from plant-derived compounds, these hormones can be specially compounded by pharmacists to create individualized doses based on each patient’s needs. This personalized approach allows treatment to better align with the body’s natural hormone balance. While certain bioidentical hormone products are FDA-approved, compounded formulations are not; however, customized dosing may improve tolerability and provide a more tailored alternative to synthetic hormone therapies.